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KMID : 1123920160300010027
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Korean Journal of Oriental Physiology and Pathology
2016 Volume.30 No. 1 p.27 ~ p.32
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Inhibitory Effects of Radix Pulsatillae Extract on Insoluble Glucan Synthesis and Adhesion of Streptococcus mutans
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Kim Kang-Ju
Park Bog-Im
Min Jae-Hong
Chae Min-Suk
Lim Jae-You
Son Hyeok-Jin
Lee Gi-Hoon
An So-Youn
Jeon Byung-Hoon
Choi Na-Young
You Yong-Ouk
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Abstract
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Streptococcus mutans plays a virtal role in trigering dental caries establishment due to its ability to synthesize two significant factors. The two factors are organic acids and glucans. The former demineralized dental enamel and the latter mediates the attachment of bacteria to tooth surface. It is believed that demineralization of dental enamel and attachment of bacteria are the crucial events that indicate and develop dental caries. For this reason, we studied the effect of the ethanol extracts of Radix Pulsatillae on the growth and acid production of S. mutans. Ethanol extracts of the Radix Pulsatillae showed concentration dependent inhibitory activity against the growth and acid production of S. mutans, and produced significant inhibition compared to the control groups (p<0.05). The extracts inhibited S. mutans adherence to hydroxyapatite treated with saliva, and cell adherence was repressed by Radix Pulsatillae. the ethanol extract of Radix Pulsatillae showed remarkable inhibition of glucosyltransferase, which synthesizes water insoluble glucan form sucrose. Phytochemical analysis showed Radix Pulsatillae contained major components such as phenolic compounds, glycosides, steroids, terpenoid, and saponin. These results suggest that Radix Pulsatillae may have anti-cariogenic properties, which may be related with major components such as phenolic compounds, glycosides, steroids, terpenoid, and saponin.
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KEYWORD
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Radix Pulsatillae, Dental caries, Streptococcus mutans, Bacteria, Glucan, Adhesion
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